For example, one study in rats found that CBD injections reduced pain response to surgical incision, while another rat study found that oral CBD treatment significantly reduced sciatic Remedy Leaf CBD Oil nerve pain and inflammation (5Trusted Source, 6Trusted Source).
Several human studies have found that a combination of CBD and THC is effective in treating pain related to multiple sclerosis and arthritis.
An oral spray called Sativex, which is a combination of THC and CBD, is approved in several countries to treat pain related to multiple sclerosis.
One study of 47 people with multiple sclerosis examined the effects of taking Sativex for one month. The participants experienced improvements in pain, walking, and muscle spasms. Still, the study didn’t include any control group and placebo effects cannot be ruled out (7Trusted Source).
Another study found that Sativex significantly improved pain during movement, pain at rest and sleep quality in 58 people with rheumatoid arthritis (8Trusted Source).
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